The most important slicer settings relate to controllling the speed at which the plastic is extruded. These key settings are filament diameter, layer height, extrusion width and print speed.
Typically, the filament diameter over the material and the layer height over the part are the same. Then you should set the same extrusion widths and speeds for each feature type (e.g. outer wall, filling etc.). Other slicer settings that need to be mastered to be effective in 3D printing are those that control the creation of the substrate. These enable overhangs and bridges which are critical for pressure parts without having to be subsequently processed.
Testing is the only effective way to create slicer configurations because third-party slicer configurations may not work as effectively on your particular machine. This applies to proprietary slicers and printers such as the SAAM series with automatic cloud slicing with ClCloud. The best tip for creating great slicer configurations is an easy start. Isolate the features you value most, start with the easiest and work your way through to the hardest. You should also validate these settings with as many 3D prints as possible.