If you try to enjoy the VR experience without glasses, you will not see the picture of the game clearly and it may change how you see the game you are playing. If you do without your glasses and see blurry, not using them during the game will make this setting even more difficult.
The only reservation against using glasses is that their VR experience is not really terrible even without glasses. If you are wearing glasses for mild astigmatism, or if you have not been told that you need to wear them all the time, you may be able to get away with just adjusting the focal length and IPD on your headset. On the other hand, not every VR headset offers these options. For an optimal viewing experience, try putting on your glasses when playing VR.
Adjust your headset when wearing glasses.
When you put on the headset for the first time, make sure you have your glasses on so that there is enough space between them and the lens. This will ensure that your experience is comfortable and you can easily adjust it if you make your room visible.
Depending on the headset, you can adjust the focal length and IPD to get a good fit, but what’s going on inside the headset isn’t the only thing that matters. Unlike other users, those of us who wear glasses get two different accessories pressed into our faces at the same time.